Extra-curricular Internship - Coscia Group

APPLICATION CLOSING DATE: October 9th, 2025.

Application instructions

Please apply online by submitting a single document that includes:

• a CV.
• a motivation letter in English

Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

In the Coscia Research Group within the Structural Biology Centre , we study the molecular mechanisms of thyroid function and disease, as well as thyroid hormone pathways, using integrative structural biology approaches across scales: from high resolution structures to organoids.

We are seeking a motivated intern to join our team and contribute to advancing research on the molecular interactors of thyroglobulin, the main thyroid hormone precursor. The intern will be involved in a project whose aim is to develop cryo-EM, biochemistry, biophysics and cellular methods to study the thyroglobulin interactors in health and disease.

Key tasks and activities:

• Cloning, Production of recombinant proteins, biophysical and cellular assays related to proteins of interest
• Structural characterisation, modelling and analysis of collected data
• Reporting to the group leader and write reports regularly, collaborating with the team

Essential requirements

• MSc in Chemistry, Biochemistry or related subject
• Experience in structural biology and biophysics
• Experience of protein structure analysis
• Fluency in English - HT is an international research institute

Preferred requirements

• Prior learning experience with Linux
• Knowledge about cryo-EM pipelines

Organizational and social skills

• Excellent communication and team working skills.
• Rigour in reporting and analysing experimental data

Why Human Technopole

• HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.
• Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.
• We believe that highly diverse teams yield the best and most innovative results.
• We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.

What we offer

• Meal delivery
• Guest House upon availability, if needed.
• Access to all training initiatives targeted to HT scientists.
• International research environment with networking and training opportunities.
• Hands-on experience with real-world research projects addressing compelling scientific questions and applying state-of-the-art technologies.
• Supervision by experienced researchers providing personalized feedback and career advice.

Special consideration will be given to candidates who are part of the protected categories list, according to L. 68/99.

Number of positions offered: 1

Internship duration: 12 months

Reimbursement: 800€ gross per month

The position is based in Milan.

The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favor of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and/or obstructive circumstances.